Guang-Cheng Wang

Design, synthesis and anti-browning mechanistic study of Trolox derivatives with dual antioxidant and tyrosinase inhibitory properties.

To obtain molecules with dual activities of antioxidant effect and tyrosinase inhibition, a new series of Trolox derivatives (5a-5g) were constructed by incorporating thiosemicarbazone moieties into Trolox based on the molecular hybridization principle. In vitro antioxidant and tyrosinase inhibition assays showed that...