Author

Guang-Ji Zhang

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Open access Sep 2026

Candidate Spatial Niches Associated with Gastric Cancer Metastasis and Treatment Resistance: Functional Classification, Evidence Boundaries, and a Translational Framework

Gastric cancer metastasis and poor treatment responses are spatially heterogeneous; however, single-marker positivity, cellular enrichment, or simple colocalization alone is insufficient to establish a functionally meaningful spatial niche. Within this framework, “treatment resistance” encompasses primary nonresponse,...

Yi Huang, Jing-Cheng Zhang, Jiaheng Lou et al. · Cells · 0 citations

Open access Jul 2026

Huangjin Shuangshen decoction alleviates chronic atrophic gastritis by suppressing TNF/NF-κB signaling and promoting CFTR-associated gastric mucosal barrier repair

HJSS alleviates MNNG-induced CAG by attenuating inflammatory injury and promoting the recovery of gastric mucosal barrier-associated molecular features, supporting an inflammation–barrier mechanism underlying the action of HJSS in CAG.

Shuo Zhang, Shuya Zhang, Mengyi Wang et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

MCT4 drives HCC progression by activating MMPs and polarizing M2 macrophages

It is demonstrated that MCT4 drives HCC progression through two complementary mechanisms: enhancing MMP-mediated invasion and metastasis, and promoting immunosuppressive M2 macrophage polarization.

Kaiyuan Zhang, Xiaochen Ni, Chuhang Wang et al. · Frontiers in Immunology · 0 citations