Ovarian microenvironment remodeling in premature ovarian insufficiency: From hormone replacement to regenerative strategies with mesenchymal stem cells and exosomes.
Premature ovarian insufficiency (POI) is a heterogeneous disorder characterized by loss of ovarian function before age 40, causing infertility, hypoestrogenism-related complications, and significantly impaired quality of life. Although hormone replacement therapy (HRT) remains the standard treatment for symptom relief...