Guang-Lu Wang

Pyrazine synthesis: a century-long evolution from condensation to modern catalytic strategies

Pyrazine (1,4-diazabenzene) is a privileged nitrogen-containing heterocycle of considerable importance in pharmaceuticals, food flavourings, agrochemicals, and functional materials. Since its first deliberate synthesis in 1908, the methods for pyrazine construction have undergone a remarkable evolution spanning more th...