Lactate-Induced H3K18 Lactylation Attenuates T-Cell Activation and Upregulates PD-L1 in Esophageal Squamous Cell Carcinoma
Background: Immune checkpoint blockade targeting the Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) axis has demonstrated clinical activity in esophageal squamous cell carcinoma (ESCC). However, therapeutic responses remain limited in a substantial proportion of patients. Metabolic reprogramming and lactat...