Guanghui Ren

KAT8-mediated epigenetic modifications: Physiological functions, heterogeneity in disease, and advances in targeted development

This work provides a comprehensive framework that clarifies recent controversies—such as whether H4K16ac primarily governs transcription or replication timing, and which KAT8-containing complex catalyzes, which acetylation mark—and establishes a rationale for future precision-targeting strategies and biomarker development grounded in KAT8 functional heterogeneity.