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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Guanran Ding

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Review Open access Sep 2026

The oral–lung axis in lung cancer: microbial translocation, immune reprogramming, and clinical implications

The oral–lung axis describes microbial and inflammatory exchange between the oral cavity and the lower respiratory tract. Its relevance to lung cancer is supported by the detection of oral-associated taxa in lower-airway samples, epidemiological links between periodontal disease and lung cancer risk, and experimental e...

Xiang-Liang Liu, Guan-Ran Ding, Jin Lu et al. · 0 citations
Review Aug 2026

The ER stress-autophagy axis in cancer-induced muscle wasting: Unveiling the IRE1α/XBP1 pathway as a therapeutic target.

This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...

Guan-Ran Ding, Wang Yang, Yi-Xin Zhao et al. · 0 citations

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