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Guansai Liu

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Review Open access 2026

Therapeutic oligonucleotides revisited: Focus on siRNA and antisense technologies

This review first provides a concise overview of the mechanistic principles underlying oligonucleotide function and commonly employed chemical modification techniques, and highlights recent advancements in receptor-mediated delivery systems for extrahepatic targeting, and dual-targeting oligonucleotide engagement strategies.

Liuhai Chen, Jiahao Xu, Jin Li et al. · 2 citations