Genome-wide coexpression analysis of intact tissue samples is a powerful approach for identifying reproducible signatures of cell types and states, since it can survey vast numbers of individuals, cells, and transcripts. However, it can be difficult to optimize gene coexpression network construction and compare results...
Rebecca Eliscu, Gugene Kang, Patrick G. Schupp et al.· bioRxiv· 0 citations
By comparing CoPA projection patterns between normal and pathological human brain samples using differential CoPA, this work identifies gene coexpression modules that are uniformly and reproducibly dysregulated in specific neocortical cell types in Alzheimer’s disease or schizophrenia.
Overexpression of CHCHD2 in METTL5-KO NPCs rescued proliferation and partially rescued oxidative metabolism in NPCs and ventricle formation in organoids, highlighting a previously uncharacterized connection between CHCHD2, oxidative metabolism, and METTL5-mediated regulation of human neurogenesis.
Elena M. Turkalj, Gugene Kang, I. Liu et al.· Stem Cell Reports· 0 citations
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