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Author

Gugene Kang

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Review Open access Aug 2026

OMICON: a community resource for studying gene coexpression networks in normal and neoplastic human brain samples

Genome-wide coexpression analysis of intact tissue samples is a powerful approach for identifying reproducible signatures of cell types and states, since it can survey vast numbers of individuals, cells, and transcripts. However, it can be difficult to optimize gene coexpression network construction and compare results...

Rebecca Eliscu, Gugene Kang, Patrick G. Schupp et al. · 0 citations
Open access Aug 2026

Coordinated dysregulation of modular gene activity in human neuropathologies

By comparing CoPA projection patterns between normal and pathological human brain samples using differential CoPA, this work identifies gene coexpression modules that are uniformly and reproducibly dysregulated in specific neocortical cell types in Alzheimer’s disease or schizophrenia.

Gugene Kang, M. C. Oldham · 0 citations
Open access Aug 2026

Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2

Overexpression of CHCHD2 in METTL5-KO NPCs rescued proliferation and partially rescued oxidative metabolism in NPCs and ventricle formation in organoids, highlighting a previously uncharacterized connection between CHCHD2, oxidative metabolism, and METTL5-mediated regulation of human neurogenesis.

Elena M. Turkalj, Gugene Kang, I. Liu et al. · 0 citations

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