Review
Open access
Sep 2026
Targeting subchondral osteoporosis in osteoarthritis: biomechanical crosstalk and the therapeutic rationale for inflammatory microenvironment remodeling
Current osteoarthritis (OA) management remains largely symptom-directed, while the contribution of osteoporosis (OP)-related and OA-associated subchondral remodeling to disease heterogeneity remains uncertain. This review integrates macroscopic load redistribution and lower-limb malalignment with local osteoimmune proc...
Ming-Li Han, Long-Fei Han, Su-Yan Zhang et al.
· Frontiers in Immunology · 0 citations