Identification of B-cell senescence-related key genes and mechanisms in Alzheimer's disease through transcriptomic sequencing combined with Mendelian randomization analysis and experimental verification
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. Currently, no treatment method can treat AD completely successfully. Objective This work seeks to uncover new genetic signatures linking B-cell senescence to AD, elucidate the immune-related pathological m...