Photodynamic activity of a mitochondria-localized G-quadruplex-responsive fluorescent ligand: Cellular effects and photo-enhanced cytotoxicity.
Mitochondrial localization concentrates photosensitizing molecules near redox-sensitive organelles. In this study, we investigated SPN, a mitochondria-targeted G-quadruplex (G4)-responsive ligand. Photochemical characterization confirmed that SPN generates robust light-triggered ROS and exhibits photooxidative activity...