Sinensetin, a Citrus Polymethoxyflavone, Alleviates High-Fat Diet-Induced Colonic Ferroptosis via the TRPV4/Ca2+ Signaling Pathway
Long-term high-fat diet (HFD) strongly induces colon injury and metabolic disorders, with ferroptosis as a key mechanism. Sinensetin, a natural polymethoxyflavone, exhibits exceptional bioactivity; however, its potential to ameliorate HFD-induced colonic ferroptosis and underlying targeted mechanisms remains unclear....