Oxidized sodium alginate/carboxymethyl chitosan/γ-polyglutamic acid injectable hydrogels enabling pH-responsive synergistic delivery of antimicrobial agents and metal-polyphenol nanoparticles for diabetic foot ulcer healing.
Chronic diabetic wounds have become a major global health challenge due to the vicious cycle driven by infection, oxidative stress, and inflammation. To address this issue, researchers developed a pH-responsive injectable hydrogel (SCP@QCNPs&DOX). The hydrogel is composed of oxidized sodium alginate, dihydrazide-modifi...