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Author

Gui-Yang Zhang

2 papers indexed here

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Oct 2026

Self-assembly prodrugs for controlled singlet oxygen release and resistance modulation in deep-tumor photodynamic therapy.

Photodynamic therapy (PDT) offers spatiotemporally controlled tumor ablation via photosensitizer-mediated singlet oxygen (1O2) generation, yet its application to deep-seated solid tumors remains fundamentally constrained by limited light penetration and tumor hypoxia. Endoperoxides (EPOs), which reversibly capture and...

Zhi-Yao Li, Wei Yang, Jian-Wu Tian et al. · 0 citations
Oct 2026

A tunable brain-targeted PEGylated ginsenoside Rg1 derivative disrupts the ROS-mediated inflammasome-pyroptosis cascade to ameliorate Alzheimer's cognitive deficits.

The pathogenic cascade of oxidative stress, neuroinflammation, and pyroptosis serves as a core driving factor in the pathogenesis and progression of Alzheimer's disease (AD). Although ginsenoside Rg1 exhibits pleiotropic neuroprotective activities, its poor blood-brain barrier (BBB) permeability severely hinders its cl...

Xing Zhu, Hao-Yu Liang, Lei Fan et al. · 0 citations

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