Author

Gui-Hua Duan

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Open access Sep 2026

TMEDRP: decoding tumor-intrinsic and microenvironmental signatures for clinical drug response prediction

TMEDRP is a novel two-stage learning framework that integrates tumor-intrinsic signatures and TME-specific components for enhanced clinical drug response prediction and exhibits promising zero-shot generalization across unseen cancer lineages and novel compounds, suggesting its robustness across diverse scenarios.

Ya-Bin Kuang, Hao-Chen Zhao, Yi Luo et al. · Bioinformatics · 0 citations

Open access Jul 2026

Momentum contrast-enhanced multimodal representation learning for drug synergy prediction

Abstract Motivation Accurate prediction of synergistic drug combinations can accelerate anticancer combination discovery. Existing methods inadequately model higher order drug–drug–cell-line interactions and drug–disease associations and remain sensitive to sparse and noisy multiomics data, limiting generalization to u...

Yunxia Gu, Xindi Huang, Lifen Shi et al. · Bioinform. · 0 citations