Glutamine synthetase deficiency triggers mitochondrial oxidative stress and a ribotoxic stress response during acute hepatic metabolic crisis.
BACKGROUND & AIMS Chlorfenapyr (CHL) is associated with high acute lethality in humans, with a case fatality rate exceeding 80%. However, the mechanisms underlying its hepatotoxicity remain poorly understood. METHODS Transcriptomic, proteomic, and metabolomic analyses were combined with assessments of mitochondrial m...