Gulacti Topcu

Short and efficient synthesis of the natural triterpenoids α- and β-amyrins with detailed in silico screening and in vitro anticancer evaluation against breast and prostate cancer cells.

α- and β-Amyrins are biologically important pentacyclic triterpenoids that occur at low levels in natural sources, making their isolation difficult. In this study, a simple and cost-effective semisynthetic route was developed to obtain α- and β-amyrins from ursolic acid and oleanolic acid in three steps, and the produc...