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Author

Gun-Ho Jang

2 papers indexed here

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Sep 2026

Abstract B066: Convergent cell-state programs characterize BRCA2 -reversion-independent resistance in pancreatic cancer

Most patients with pancreatic ductal adenocarcinoma (PDAC) present with advanced-stage disease, for which systemic therapy is the mainstay, highlighting the need to identify therapeutically vulnerable molecular tumor subgroups. Homologous recombination deficiency (HRD), arising from germline or somatic alterations in...

J. Romero, Yi-Fan Wang, Edward Shanbedi et al. · 0 citations
Sep 2026

Abstract B011: HMGA2 controls fibroblast skewing and immune infiltration in basal pancreatic cancer

The basal-like subtype of pancreatic ductal adenocarcinoma (PDAC) is associated with poor outcomes and increased chemoresistance. Expression of high mobility group AT-hook 2 (HMGA2), a chromatin architectural protein, marks basal PDAC cells. Recent efforts to understand the tumor microenvironment (TME) of PDAC have e...

Naomi Yamamoto, S. Dobersch, Tess M. Robertson et al. · 0 citations

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