Craniotomy, a neurosurgical procedure for treating brain tumors, epilepsy, and cranial bleeds, carries a 1-5% infection risk, often due to Staphylococcus aureus biofilm formation, rendering infections tolerant to antibiotics and immune clearance. Treatment often requires multiple surgeries, heightening patient mo...
Artha Govind Lotlikar, Tammy Kielian, Gunjan Kak et al.· Journal of Immunology· 0 citations
This findings reveal that S. aureus biofilms exploit TLR2-MyD88 signaling to reprogram neutrophils into immunosuppressive G-MDSC-like cells, which highlights both bacterial-derived TLR2 ligands and host TLR2 signaling as promising therapeutic targets to restore antimicrobial immunity in neurosurgical infections.
A. Ogunware, Gunjan Kak, Tammy Kielian et al.· Journal of Immunology· 0 citations
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