Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we introduce an integrated platform with three nove...
This review systematically elaborates on the pathological characteristics and molecular mechanisms of aging, analyzes the application paradigms of multi-omics in biomarker screening, mechanism elucidation, and high-throughput screening, and discusses the core value and technical bottlenecks of AI in target prediction,...
Li-Juan Gao, Yong-Sheng Qin, Yudai Xu et al.· Frontiers in Aging· 0 citations
ABSTRACT Impaired corneal wound healing in diabetes remains a major clinical challenge, driven by defective autophagy, metabolic dysregulation, and sustained inflammation within a high‐reactive oxygen species (ROS) microenvironment. Here, we engineered a ROS‐responsive ocular delivery system based on N1‐(4‐boronobenzyl...
Jiaxin Wu, Wan-Ying Chen, Haijiang Qiu et al.· Advancement of science· 0 citations
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