Guo-Chao Zhang

The inflammation–immunosuppression loop as a driver of immune dysfunction and secondary infections in severe COVID-19

Severe COVID-19 is strongly associated with a high incidence of secondary bacterial, fungal, and viral infections, which substantially contribute to prolonged hospitalization and increased mortality. Although cytokine storm characterized by elevated levels of IL-6, TNF-α, and IL-1β has long dominated the understanding...