Guo Chen

The crosstalk between alternative splicing and histone ubiquitination modulates fast chemical reprogramming to pluripotency.

Cellular reprogramming has revolutionized regenerative medicine. Recently, we develop a fast chemical reprogramming (FCR) system; however, the underlying molecular mechanisms remain largely unknown. Here, we investigated the dynamics of RNA-binding protein (RBP) expression and alternative splicing (AS) events in the FC...