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Guo-Dong Liu

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Open access Sep 2026

Dual DNMT–EZH2 Inhibition as a Stroma-Directed Strategy in Castration-Resistant Prostate Cancer: A Commentary

Background: Castration-resistant prostate cancer (CRPC) remains a lethal progression state despite androgen-deprivation therapy, driven by epigenetic plasticity and a fibrotic tumour microenvironment. Single-agent epigenetic inhibitors have limited activity in solid tumours, partly because compensatory H3K27me3-mediate...

Rong-Xin Chang, Guo-Dong Liu · 0 citations

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