Author

Guo-Hang Shen

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Open access Oct 2026

Single-cell eQTL Mendelian randomization reveals the monocyte-associated PRKCB-CTSL axis as a candidate regulatory pathway and potential therapeutic target in rheumatoid arthritis.

OBJECTIVES Rheumatoid arthritis (RA) involves persistent immune dysregulation, but cell-specific genetically regulated pathways remain unclear. We integrated cell-specific genetic and multi-omics evidence to prioritize candidate regulatory pathways. METHODS cis-eQTLs from 17 immune-cell populations were integrated wi...

Peng-Li Wang, Guo-Hang Shen, Wen-Hua Liao et al. · Clinical Rheumatology · 0 citations

Open access Aug 2026

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

Iron dysregulation has emerged as a contributor to osteoarthritis (OA), yet the cell‐communication mechanisms connecting iron‐related genetic signals to joint degeneration remain insufficiently defined. Here, we established an integrative computational framework combining transcriptomic screening, machine learning, Men...

Yue Zhou, Guo-Hang Shen, Lijing Si et al. · Journal of cell communicatio... · 0 citations

Open access Aug 2026

Integrative single-cell eQTL and multi-omics analyses reveal AIM1 and ANXA1 as immune-related hub genes and potential therapeutic targets in head and neck cancer

An integrative single-cell eQTL-driven multi-omics framework to identify immune cell-specific causal genes and prioritize drug-repurposing candidates for HNC supports AIM1 and ANXA1 as promising biomarkers and therapeutic entry points for precision drug development.

Zhangwei Xue, Guo-Hang Shen, Gongbiao Lin et al. · Frontiers in Oncology · 0 citations