Author

Guo-Liang Chen

2 papers indexed here

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Open access Sep 2026

Design, Synthesis and Antitumor Activity Evaluation of Novel Dual G9a/EZH2 Inhibitors

Targeting the crosstalk between histone methyltransferases G9a and EZH2 represents a promising strategy for cancer therapy. To improve upon our previously reported dual inhibitor SU08, we rationally designed and synthesized five series (SU, UA, UB, N, and L) of novel G9a/EZH2 dual inhibitors, incorporating diverse pyri...

Ya-Jie Shi, Qiu-Yue Zhang, Ma-Zhong Zhang et al. · Molecules · 0 citations

Sep 2026

Asymmetric Hydroformylation of Aryl Vinyl Ethers to Chiral 2-Aryloxypropanals: Access to Aryloxypropionic Acid Herbicide Precursors.

Enantiopure aryloxypropionic acid herbicides are of considerable importance in modern crop protection, creating a strong demand for efficient catalytic approaches to their synthesis. Herein, we report a Rh/(S,R)-DTB-YanPhos-catalyzed asymmetric hydroformylation of readily available aryl vinyl ethers, affording chiral 2...

Jian-Qiang Zheng, Lin-Na Qi, Cai You et al. · Chemistry · 0 citations