Hippocampal Caspase-4 non-canonical inflammasome activation is associated with microglia-synapse crosstalk disruption and drives depression-like behaviors.
Whether hippocampal non-canonical inflammasome activation drives microglial neuroinflammation and impairs synaptic plasticity to precipitate depression-like behavior and Targeting the Caspase-4 non-canonical inflammasome warrants further investigation as a potential, may offer a novel immunotherapeutic strategy for dep...