Author

Guo-Qiang Pan

2 papers indexed here

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Sep 2026

Breaking the Lipid Bottleneck: A Mitophagy-Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy.

Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME-responsive nanometabolic regulator, ZnO2@Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferroptosis to enhance anti-tumor immunity. ZFH specifical...

Shao-Peng Zhang, Guo-Qiang Pan, Qin-Nie Xu et al. · Small · 0 citations

Open access Aug 2026

Hypoxia drives ferroptosis resistance and immunosuppression in hepatocellular carcinoma by inducing UBASH3B-mediated glutamine metabolism reprogramming and CXCL8 expression

A novel interaction between hypoxia, glutamine metabolic reprogramming, and immune suppression in HCC progression is uncovered, positioning UBASH3B as a promising therapeutic target for overcoming hypoxia-induced treatment resistance.

Guo-Qiang Pan, Shaokai Zhang, Xi Wang et al. · Redox Biology · 0 citations