Open access
Sep 2026
FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma
A novel FTSJ3‐HSPA5‐BOP1‐DRP1‐SREBP1‐SREBP1 axis that integrates RNA methylation with SUMOylation, mitochondrial dynamics and lipid metabolism to promote LUSC progression is delineated, nominating FTSJ3 as a therapeutic target for this cancer.
Qin Hu, Jia-Heng Lin, Yi-Fei Zhu et al.
· Advancement of science · 0 citations