Guo-Wen He

Design, Synthesis, and Pharmacological Evaluation of Sulfur‐Containing Pitolisant Analogs as Potent H3R Antagonists for Epilepsy Therapy

Although multiple antiseizure drugs (ASDs) are clinically accessible, epilepsy remains a debilitating neurological disorder with a high unmet need for more effective and better‐tolerated therapies. Antagonism of the histamine H3 receptor (H3R) represents a promising alternative strategy, exemplified by the clinically a...