Author

Guo-Zhen Chen

2 papers indexed here

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Open access Sep 2026

Honokiol Alleviates Dry Eye-Related Corneal Epithelial Damage by Activating SIRT3/PINK1-Mediated Mitophagy

Background: Dry eye is a common ocular surface disease characterized by corneal epithelial damage, yet effective therapies targeting mitochondrial dysfunction remain limited. Purpose: To investigate the protective effects of honokiol (HKL) against dry eye-related corneal epithelial injury and elucidate the underlying m...

Yu-Lei Huang, Xin-Dan Cao, Xin-Lin Yan et al. · Drug Design, Development and... · 0 citations

Open access Aug 2026

An ICD gene set-derived immune contexture signature for colorectal cancer prognosis: integrated single-cell and bulk transcriptomic analysis with external validation.

Immunogenic cell death (ICD) links tumor cell demise with antitumor immunity, but the transcriptional features associated with ICD gene expression patterns and their prognostic significance in colorectal cancer (CRC) remain areas of active investigation. This study integrated single-cell and bulk transcriptomic data fr...

Shu-Qiong Su, Guo-Zhen Chen, Shi-Yao Yang et al. · Cancer Treatment and Researc... · 0 citations