Author

Guozhong Zhou

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Open access Oct 2026

Integrative single-cell and bulk transcriptomics with reverse network pharmacology prioritizes macrophage-associated candidate genes in Lyme arthritis

Introduction Lyme arthritis (LA) involves complex immune dysregulation, and macrophages contribute centrally to persistent joint inflammation. However, synovial macrophage heterogeneity and its potential relevance to therapeutic intervention remain incompletely defined. Methods We integrated scRNA-seq data from Borreli...

Yan Dong, Yan-Shuang Luo, Yan-Tong Chen et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

Bioinformatics analysis of potential molecular markers and immunological characteristics shared between post-treatment Lyme disease syndrome and rheumatoid arthritis

PTLDS and RA share certain common features at the level of immune-inflammatory regulation, and ZNF83 may serve as a potential feature regulatory molecule involved in the immune processes of both diseases.

Yantong Chen, Xingui Guo, Xinyuan Xu et al. · Frontiers in Immunology · 0 citations

Review Open access Jul 2026

Beyond AUC: a clinician’s guide to building and trusting prediction models in oncology—a narrative review

This review provides a practical, clinician-oriented guide to the statistical principles and advanced methods for developing, validating, and interpreting robust prediction models and synthesized key statistical principles and illustrative examples to guide clinicians and researchers through model development, validati...

Xuexing Wang, Youxian Dou, Yufeng Wang et al. · Frontiers in Oncology · 1 citation