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Guochun Lou

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Open access Nov 2026

KLHL6 drives colorectal cancer liver metastasis through ubiquitin-mediated degradation of MBD2 that triggers CLDN4 activation

Liver metastasis is the leading cause of death among patients with colorectal cancer (CRC) and remains a major clinical challenge because durable therapeutic options are limited. Metastatic progression depends on extensive transcriptional plasticity, yet how epigenetically silenced prometastatic genes are reactiv...

Wen-Wen Chen, Xiao-Yun Yang, Guochun Lou et al. · 0 citations

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