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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Guoping Peng

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Open access Aug 2026

HSPA8 orchestrates SNARE complex assembly to drive extracellular vesicle-mediated spread of p-tau217 in Alzheimer's disease

Investigating the mechanisms underlying the reduction of p-tau217+ EVs to uncover AD therapeutic targets reveals a role of HSPA8 in regulating the MVB-mediated EV release and tau propagation, and highlights HSPA8 as a promising therapeutic target for modifying AD progression.

Bin Xu, Zhen Guo, Jun Chen et al. · 0 citations
Open access Aug 2026

Head-to-head comparison of plasma biomarker assays across platforms for amyloid pathology in a multicenter cohort.

Several plasma p-tau217 assays demonstrated strong diagnostic accuracy for amyloid PET positivity in this cross-sectional memory-clinic cohort, although performance varied across platforms and cutoff transferability was limited.

Xinyi Lv, Kaiyuan Shen, Qianhua Zhao et al. · 0 citations

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