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Open access Sep 2026

A recombinant Newcastle disease virus-vectored multi-epitope vaccine confers protection against QX-like infectious bronchitis virus in chickens

Infectious bronchitis virus (IBV) QX-like (GI-19) genotype dominates global poultry flocks, yet Mass-type vaccines fail to confer cross-protection. We developed a recombinant Newcastle disease virus (NDV) LaSota vector expressing conserved IBV S1 B-cell hotspots paired with S1-derived BF2-restricted CTL epitopes (rND...

Fei Wang, Jia-Nan Xie, Guo-Yuan Wen et al. · 0 citations
Aug 2026

A novel TK/gE-deleted pseudorabies virus vaccine expressing CCL3L1 enhances humoral immunity by stimulating the dendritic cell-T follicular helper-germinal center axis.

Pseudorabies virus (PRV) remains a major threat to the swine industry, particularly due to the emergence of highly virulent PRV variants that have caused severe outbreaks in Asia in recent years. These emerging strains exhibit enhanced pathogenicity and immune evasion, resulting in insufficient protection by traditiona...

Lun Yao, Si-Wen Hao, Chengjun Zhang et al. · 0 citations

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