Review
Open access
Sep 2026
The acidic tumor microenvironment in hepatocellular carcinoma: a barrier to adoptive cellular immunotherapy
The metabolic interface between tumor and immune cells is an emerging determinant of immunotherapy resistance, yet its therapeutic exploitation in hepatocellular carcinoma (HCC) remains limited. Adoptive cellular immunotherapies, including NK cell infusion, tumor-infiltrating lymphocytes (TILs), and chimeric antigen re...
Jing-Nan Xiong, Guozirui Mou, Taduoji Ze et al.
· Frontiers in Immunology · 0 citations