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Gustavo Barbosa Reis

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Review Open access Jul 2026

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules

A comparative, structure-driven analysis of PD-L1 complexes deposited in the Protein Data Bank is presented and it is demonstrated that distinct inhibitory modalities converge on the same functional CC′FG hotspot region while employing fundamentally different neutralization mechanisms.

Imma Capriello, T. Moreira Pereira, Gustavo Barbosa Reis et al. · 0 citations