Author

Gustavo Tapia-Urzúa

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Open access Aug 2026

CTCF delimits a DNA methylation transition at the intergenic region between the embryonic and adult α-globin genes

A conserved role of CTCF is supported in preventing DNA methylation spreading and gene silencing of cell-type-specific genes along differentiation, and a similar role of CTCF on DNA methylation and gene expression in the human orthologous gene HBA2.

Gustavo Tapia-Urzúa, H. N. Núñez-Martínez, Sylvia Garza-Manero et al. · Epigenetics · 0 citations

Aug 2026

TIF1γ regulates stability of regulatory T cells during inflammation

It is shown that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge, and TIF1γ is identified as a critical regulator of Treg cell stability that restrains β-catenin–TCF7 signaling.

Eugenio Contreras-Castillo, Jesús Daniel Zambrano-Romero, H. N. Núñez-Martínez et al. · Nature Immunology · 1 citation