Hyphenated Mass Spectrometry-Based Strategies for Characterizing Oligomers of α‑Synuclein in Parkinson’s Disease
The pathological aggregation of α-synuclein (α-syn), an intrinsically disordered protein that regulates synaptic vesicle trafficking in the brain, is a defining molecular feature in Parkinson’s disease (PD). Early oligomeric assemblies are widely considered the most neurotoxic species, yet their structural features rem...