Author

H. A. Khafagy

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Open access Oct 2026

The interplay of the gut microbiome, tryptophan metabolites, and uremic toxin generation in chronic kidney disease progression

Chronic kidney disease (CKD) affects roughly 850 million people worldwide, yet the cardiovascular and immune-related mortality that classical uremic markers cannot fully explain remains the central clinical problem. Much of the small-solute uremic toxin pool is now traceable to gut microbial metabolism, and tryptophan-...

T. Zayan, H. A. Khafagy · World Advances in Renal Medi... · 0 citations

Open access Oct 2026

Acute kidney injury-to-chronic kidney disease transition: Maladaptive senescence, epigenetic reprogramming, and the translational frontier

Acute kidney injury (AKI) is a consistent precursor of incident and progressive chronic kidney disease (CKD). The transition reflects failed tubular repair followed by tubular atrophy, peritubular capillary rarefaction, and progressive interstitial fibrosis. Maladaptive cellular senescence is driven by persistent DNA-d...

T. Zayan, H. A. Khafagy · World Advances in Renal Medi... · 0 citations

Review Open access Sep 2026

Cosmic kidney disease in spaceflight and terrestrial nephrology: Mechanisms and translation

Astronauts experience nephrolithiasis at incidence rate ratios two- to seven-fold higher than pre-flight estimates, a disparity historically attributed to microgravity-induced bone demineralization. The 2024 Cosmic Kidney Disease study reframed this paradigm by demonstrating a primary renal tubulopathy with direct rele...

T. Zayan, H. A. Khafagy · World Advances in Renal Medi... · 0 citations