Review
Open access
Oct 2026
Three-dimensional in vitro models for assessing temozolomide sensitivity in glioblastoma.
Three-dimensional culture systems, including tumor spheroids and organoids, are emphasized, which more effectively recapitulate tumor architecture, cell-cell interactions, and drug penetration gradients than conventional two-dimensional models.
Andresa Hiromi Sakai, M. Sakalem, Luiza Caroline Oliveira Rocha et al.
· Frontiers in Neuroscience · 0 citations