H. Alharbi

Molecular modelling, cytotoxic activity, and carbonic anhydrase inhibition of new pyridazine-thiazole hybrid compounds

The pharmacokinetics SwissADME in silico studies indicated that the low molecular weight conjugates respect Lipinski’s rule of five, with optimal value of lipophilicity, and exhibit blood-brain barrier permeability, while bulky derivatives showed a reduced gastrointestinal absorption (GI) absorption with increased mol...