H. Azevedo

Discovery of Long-Acting Bifunctional Compounds with Muscarinic M3 and Histamine H1 Receptor Antagonism for the Treatment of Rhinitis

Rhinitis is a heterogeneous inflammatory condition of the upper airway mucosa. Chronic symptoms are often refractory to first-line intranasal antihistamines and corticosteroids, particularly in mixed and nonallergic phenotypes. Add-on anticholinergic treatment alleviates rhinorrhea but is hampered by short duration o...