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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

H. Bange

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Open access Sep 2026

From Phenotypic Screening to Target and Compound Prioritization for Autosomal Dominant Polycystic Kidney Disease.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a progressive kidney disorder with limited therapeutic options, highlighting an urgent need for safer, long-term treatments. This study presents a multi-step computational and experimental approach to identify and assess target-based hypotheses for mechanisms unde...

D. Araripe, Margarita Iljin, H. Bange et al. · 0 citations
Open access Aug 2026

Targeted analysis of salicylate binding partners in renal epithelial cells reveals major AMPK dependency.

The findings indicate that for a large part, the effects of salicylate on targets related to cellular metabolism, cell proliferation and inflammation are dependent on its activation of AMPK, but salicylate induces mitochondrial uncoupling and inhibition of heme synthesis, while other AMPK activators do not, revealing A...

Anish A. Kanhai, K. Lodder, L. Wisse et al. · 0 citations

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