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Author

Helen E. Blackwell

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Open access Sep 2026

A Small Molecule Dual Inhibitor of agr Quorum Sensing and ATP Synthase Blocks Acute and Chronic Virulence Phenotypes in Staphylococcus aureus

The accessory gene regulator (agr) quorum-sensing system in Staphylococcus aureus plays a prominent role in acute infections caused by this common pathogen. In contrast, ATP synthase affects the ability of S. aureus to establish chronic infections and persist as small colony variants. In this study, we report that a...

Troy D. Vulpis, Jordan T. York, A. Clay et al. · 0 citations
Open access Aug 2026

Domain-swapped LuxR-type quorum sensing receptors reveal divergent ligand-response mechanisms among homologs

Key structural features governing ligand response are defined and unexpected mechanistic plasticity is revealed, providing a foundation for more informed design of next-generation quorum sensing modulators with enhanced specificity, potency, and predictable activity across diverse receptors.

Irene M. Stoutland, Susan Walker, H. Blackwell · 1 citation
Review Aug 2026

Structure-Based Insights into the Molecular Mechanisms of LuxR-Type Quorum Sensing Receptors.

Recent structural and mechanistic insights into LuxR-type receptor function are summarized, including interactions with small molecules, protein partners, and DNA, including interactions with small molecules, protein partners, and DNA.

Irene M. Stoutland, Mai V. Beauclaire, Mikael H. Elias et al. · 0 citations

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