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Author

H. Bousbaa

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Open access Sep 2026

Synthesis and Assessment of the Enantioselectivity in Antitumor Activity of a Library of Novel Chiral Flavone Derivatives

Nature represents a rich source of bioactive compounds, with flavones emerging as privileged scaffolds owing to their multiple biological activities. Their antitumor potential arises from their ability to modulate pathways implicated in cancer progression and multidrug resistance, but structural modifications are often...

C. Pinto, Flávia Barbosa, João Machado et al. · 0 citations
Open access Aug 2026

Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer

While PLK-1 inhibition exerts antitumor effects in certain in vivo contexts, the therapeutic synergy observed in vitro with Navitoclax does not consistently translate to in vivo lung cancer models, which highlights the challenges of translating combinatorial mitotic and apoptotic targeting strategies into effective in...

Bárbara Pinto, Mateus Prates-Rodrigues, D. A. B. Nobre et al. · 0 citations

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