Anti-cytokine autoantibodies are increasingly recognized as modulators of immune function and determinants of disease risk, yet their genetic basis and population-level impact remain unclear. Here we perform genome-wide association studies of autoantibodies against IL-1α, IL-6, IL-10, IFN-α, IFN-β, IFN-γ and GM-CSF in...
J. V. von Stemann, Joseph Dowsett, R. Teglgaard et al.· Nature Communications· 0 citations
BACKGROUND
Cardiomyopathy guidelines recommend routine screening of at-risk relatives with dilated cardiomyopathy (DCM). Titin-truncating variants are the most prevalent cause. However, the diagnostic yield of screening is low. Risk-based stratification could optimize screening intervals and resource allocation. This s...
S. Muller, N. Beelen, A. Paldino et al.· Circulation: Heart Failure· 0 citations
BACKGROUND
Atherosclerosis may begin in early adulthood and remain clinically silent for decades before cardiovascular disease manifests. Although silent atherosclerosis is associated with cardiovascular events and death independent of traditional cardiovascular disease risk factors, its age- and sex-specific prevalenc...
H. Bundgaard, I. García-Lunar, K. F. Kofoed et al.· New England Journal of Medic...· 0 citations
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