Open access
Aug 2026
ESM1-mediated DNMT3A suppresses cervical cancer metastasis through epigenetic regulation of ID3 expression
In vivo xenograft and experimental metastasis models validated that ESM1 depletion significantly impaired tumor growth and lung metastasis while increasing ID3 expression, identifying the ESM1/DNMT3A/ID3 axis as a novel epigenetic driver of cervical cancer and a potential therapeutic target.
Chen-Lin Yu, Chia-Liang Lin, Hsiang-Lin Lee et al.
· Cell Death Discovery · 0 citations