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Open access Jul 2026

Emergence of Disease-relevant Aberrant Epithelial Cell States in Human Alveolar Organoids.

Dysregulated alveolar epithelial repair is a central aspect of Idiopathic Pulmonary Fibrosis but it has proven challenging to reliably model alveolar epithelial cell biology in-vitro. We previously reported persistent activation of Hypoxia-inducible Factor 2 (HIF2) is a hallmark of aberrant epithelial cell phenotypes i...

H. David, A. Dietrich, C. Calvi et al. · 0 citations

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