Author

H. Devarbhavi

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Review Sep 2026

Global burden of liver disease: 2026 update.

Chronic liver disease (CLD) remains a major global health challenge, affecting more than 1.5 billion people worldwide and contributing to morbidity, mortality, and healthcare costs. Cirrhosis is the 12th leading cause of death globally and together with primary liver cancer accounts for nearly 2.4 million deaths annual...

H. Devarbhavi, Sumeet K. Asrani, J. Arab et al. · Gastroenterology · 0 citations

Open access Jul 2026

Genetics and epigenetics in tumor necrosis factor-alpha (TNF-α) and transmembrane 6 superfamily member 2 (TM6SF2) in alcohol induced liver cirrhosis

Background Alcohol dependence and cirrhosis are key outcomes of increased alcohol use, with genetic factors increasingly implicated. A functional promoter variant (rs361525) in the TNF-α gene may contribute to ALD pathogenesis, while a loss-of-function variant (rs58542926) in TM6SF2 modifies liver disease progression....

B. Shankarappa, J. Mahadevan, Pratima Murthy et al. · Frontiers in Medicine · 0 citations